What's on Your Mind

[Insertnamehere]

I suspected something like that. But that common pathway is not identical up to the end. It is possible to target different parts of it resulting in a differential modulation of its various components. Someone should work on that, that was my point.




I will never mess with my pain receptors. My pain sensation is excellent (i.e. I have a very high pain tolerance), I don't want to fuck that up.


Lidocaine is a local anesthetic, which wouldn't be suitable to alleviate a headache.






Yeah well, I wasn't asking for my whole ability to sense pain to be abolished. I'm one of the last people on this planet to argue against pain like that.

I had a fever, my airways were clogged up and I couldn't breathe half the time, I had a painful cough and a sore throat, my ears were shut (I don't know what's the term for it in English; it's the same thing that happens when you're on an airplane), and on top of that I had a headache for the second day in a row. It served no beneficial purpose and I would have liked to take away that one thing I could have controlled. As it stood, I didn't do it, because I chose not to lower my fever even though it would have meant getting rid of my headache.

As it is, the choice is either NSIDs or opioids.

Now this next bit comes from a place in which...I don't have enough time on my hands to do a proper bibliographic research for you...

I would venture the guess that having various effects, prostaglandins target different cell types and/or different cell receptors, in turn activating different signaling pathways that lead to these effects. The option would be to develop an antagonist that blocks a specific receptor related to a signaling pathway known to lead to a specific effect without affecting the rest of them.

I'm not currently aware if the entire signaling pathways related to prostaglandins and their effects are known or fully dilucidated. Making up the different components of a signaling pathway can be tricky, especially if the receptors are located in the membrane.

Given that prostaglandins seem structurally quite hydrophobic (to me, when I look at the molecule, at least) I would guess an intracellular receptor, the kind that upon binding the molecule in question turns into a transcription factor directly affecting the expression of target genes.


There is also the fact that OTC medications are mass produced and meant to be usually cheap, so in terms of cost-effectiveness, if you have a medication that can do a number of things targeting just the one effector enzyme, that is, commercially, a good thing.

[TigerLover]

The children's books lied to me. Doing the right thing frequently sucks and rarely goes rewarded.

[Sylph]

Eek!

Today is moving day for me.

I'm leaving the Main Island and moving to a Village on a smaller island;

Mind you, this is still all within our 21sq Mile territory, so I'm not moving drastically far away from my mommy

But despite our small size, each of our Parishes and Islands look and run very differently from one another;

So adjusting to living in the Village rather than in the City will be a lil challenge.


Tho I used to play and ride bikes in the area as a child, as my cousin grew up in the Village.

I grew up in the old Capital near the Sea on one of our islands and on the Shore side later on, on the Main Island.


It's amazing to think how my life is moving full circle;

Tho with only 21sq Miles, variation is pretty limited

[CellarDweller]

It's lunch and I want my Chinese food!

[Sylph]

I love when foreigners appreciate our island life;

But I love it more when we islanders show and share appreciation for one another more so!


Had a very fun and interesting cultural talk today with a St Lucian and Jamaican about games we played similar as kids and just stuff like so.


My island may be more racially diverse and mixed than a lot of others (DR and Trinidad being like us), but we all share a unified culture and history;

And it's so beautiful to think of

[InbetweenDreams]

While I can't say I have a lot of friends, I can say I'm very glad and grateful I have a few very good friends who do support and can do fun things with. Always nice to get out of the house and not worry about life for a while.

[Emiliano]

I'm about to go look at an apartment that I'm pretty sure I really want. something about finding a good apartment in this city makes it 10x as stressful as any job interview or date I've ever been on...
I hope this land lord likes me :/

[InbetweenDreams]

Well next month is going to be a big drag and was hoping to visit my sister but I will probably have to put that off until May most likely. I have to pay this medical bill and rather setting up another payment which I don't need I'm just going to pay the whole thing and just try to get by with as little as possible. Something to the order of less than $50 per week on gas/food/whatever... So in a nutshell I won't be doing jack squat next month...but after that I won't have a medical bill...

Hopefully, when October comes around I'll one of my credit cards paid off too...

[Sylph]

I'm about to go look at an apartment that I'm pretty sure I really want. something about finding a good apartment in this city makes it 10x as stressful as any job interview or date I've ever been on...
I hope this land lord likes me :/

Gurl I does feel de pain enuh!

I just recently moved myself, and my island is full of homophobes and I lucked out with a landlady who does love Gay boys;

So I'm sending ya a lil of my luck ya way darlin


Not that you'll probably need it, as pretty bitches like you tend to be liked by all lol


Stress less and play more Emily!

[Sylph]

I hate when people, especially men, feel intimidated by a strong willed and mouthed feminine guy?

They all think we're rude/vain/belligerent/unintelligent;

But like I tell them:

If you feel disdain at another's expression of pride and self love;

Then clearly the fault and problem is with you and quite honestly, it's a shame that a person who has to fight society to be comfortable in their own skin, would have to battle someone who more than likely has never experienced life in that way and yet has the audacity to judge and shame.


There is a very clear difference between being obnoxious and rude, and being assertive and unabashed in day to day life.


I'm recently noticing a trend, especially with today's global culture, and if you find yaself affronted by a situation you have no perspective on;

Think twice darlins